does blood type affect covid vaccine side effects

The data came from critically ill patients at two Vancouver hospitals, where 84 percent of those with blood type A or AB needed intubation and ventilation compared to just 61 percent of those with O or B type blood. Side effects in adults >55 after Pfizer-BioNTech vaccine (second dose) Pain at injection site (66.1%) Fatigue (50.5%) Headache (39.0%) Muscle pain (28.7%) Chills (22.7%) Joint pain (18.9%) Fever (10.9%), diarrhea (8.3%) and vomiting (0.7%) were also reported. A bigail, a 29-year-old from New York City who asked to use a pseudonym to preserve her privacy, knew to expect some side effects after she got her second Pfizer-BioNTech COVID-19 vaccine in . "Half of it is the same as the original vaccine," explains Richard Martinello, M.D., the medical director of infection prevention at Yale New Haven Health System. Water (H2O) serves as a positive control. Monday, September 14, 2020 (Kaiser News) -- The Food and Drug Administration is weighing whether to follow British . If so, how can I get that information? While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHO, and their local public health department as resources. The latest data on blood type is still preliminary. This is not a complete list of side effects and others may occur. Remember that 70 percent of your immune system is determined by the microbiome in your gut.8 At Body Ecology, we promote the use of certain (but not all) fermented foods to not only nourish you but to nourish your gut and immune system as well. The information in this story is accurate as of press time. However, for the Pfizer jab the reverse appears to be true. Read said that for some people the process was without symptoms, but for others it generated these common side-effects. Send it to us atCovidQ@mit.edu, and well do our best to provide an answer. Hoarseness: How Likely Is It to Be a COVID Symptom? Local Side Effects You may experience pain, redness, and swelling where you got the shot. The secondary outcome was severe COVID-19 illness or death. In addition, COVID-19 vaccination might offer better protection than getting sick with COVID-19.A recent study showed that unvaccinated people who already . Current authorizations are based on these previous studies, as laid out by health regulators at the Centers for Disease Control and Prevention (CDC). Prior to joining GH in 2019, Zee fostered a nutrition background as an editor at Cooking Light and is continually developing his grasp of holistic health through collaboration with leading academic experts and clinical care providers. Sat, Sun 10 a.m. 4 p.m. For blood types O and B, the average stay was nine days. Researchers have been talking about blood type and COVID-19 susceptibility for months. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Visit the MHRA Yellow Card report for the latest data on the reported side effects of Covid-19 vaccines. But in each instance, these have appeared soon after widespread use of the vaccine began. Download Some of the potential side effects of a vaccine - fever, chills, headache and fatigue - can seem very similar to the symptoms of the illness it's meant to prevent. If you haven't heard of the term "bivalent" just yet, it refers to the fact that this updated vaccine contains genetic code targeted to the original strain of virus that spreads COVID-19, known as SARS-CoV-2 in addition to parts of the Omicron-based strains that are circulating currently. As more information about the coronavirus pandemic develops, some of the information in this story may have changed since it was last updated. They have also been shown to be very good at lowering the risk of getting very sick, being hospitalized, or dying from COVID-19 if you are infected. A Top Derm Explains, 35 of the Smartest Fast-Food Choices You Can Make, Easy Brain Exercises to Boost Your Memory, Why We Should All Be Eating More Buckwheat, COVID-19 Emergency Funding Is Coming to an End. Centers for Disease Control and Prevention, you didn't experience any side effects at all, better bolster your body's immune response, other better-for-you fluids to stay hydrated, Your Privacy Choices: Opt Out of Sale/Targeted Ads, Take over-the-counter medication like ibuprofen, acetaminophen, aspirin, and antihistamines as needed, Apply a cold compress or a wet washcloth over the injection site if experiencing redness or swelling, Exercise your arm after injection to mitigate discomfort. Deep, healing sleep, reducing stress, walking or other forms of gentle exercise, plus pampering yourself, are important for helping to create a robust immune system. We call this the viral load. denotes no information is available; AST, aspartate amino transferase; LDH, lactate dehydrogenase; N/A, not applicable; RBC red blood cell. Acute stressors such as pregnancy, steroids or inflammation from cytokine activation often seen in COVID-19 patients can bring out hyperglycemia in someone not known to have diabetes/prediabetes. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion. Researchers found inconsistent findings but did identify certain trends suggesting that blood type A might predispose one to increased susceptibility to infection with SARS-CoV-2 (the virus that causes COVID-19), or that type O and Rh-negative blood groups might be protective. Those symptoms are similar in all vaccines, but in the two-dose vaccines, they are more common after the second shot. However, experts say it is too soon to be sure the J&J jab is causing the blood-clotting problem, and even if it is, the risk is very low. Patient 3 is a 32-year-old woman with a 10-year history of PNH on ravulizumab with her last dose 4 weeks prior to vaccination. I have read that it is important that a large percentage of people get the vaccine. Search for other works by this author on: Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. In short, it might feel like you have the flu. But you shouldn't be worried about any increase in side effects here, Dr. Martinello explains, as FDA regulators have seen a similar bivalent booster vaccine made by Pfizer and BioNTech for the "stealth" Omicron variant that spread rampantly last winter and those bivalent boosters were extensively studied before they were rolled out. Experts have stressed the rarity of such cases estimating they may occur in about one in 100,000 young adults who get the jab a risk lower than the chance of dying in a road accident in a year. Scientists have readily admitted that this particular batch of bivalent vaccines, targeted towards BA.4 and BA.5 sub-Omicron variants, have yet to be studied in humans officially. One theory is that antibodies may play a role. That's because of a particular type of antibody they make that attacks other red blood cells. "The resulting brownie is the same, though.". A 2012 meta-analysis found that having a non-O blood type was among the most important genetic risk factors for venous thromboembolism.5. Complement has emerged as a likely driver of the immune response and end-organ damage in COVID-19. They include: tenderness, swelling, and. Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. The clots may also form in multiple places in the body, including in the lungs. What Research Says About the Link Between COVID-19 and Blood Type, What the Blood Link Research Means for You. That means getting vaccinated and boosted, social distancing, wearing a mask in public, and washing your hands regularly, among other things. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . Both federal health officials and leading virologists polled by Good Housekeeping for this article suggest that you should expect similar side effects this time around if you experienced them after earlier vaccinations. One of these areas contains genes that determine blood type along with other genes that are known to be associated with immune function. For the primary outcome, analyses were further stratified by patients aged younger than 70 years vs 70 years or older. Notably, she took danicopan throughout her first vaccination and did not experience breakthrough hemolysis. The remaining authors declare no competing financial interests. Ann Intern Med. Our clinicians do not order blood typing routinely, other than for pregnant patients. What You Need to Know doi: https://doi.org/10.1182/blood.2021011548. Information contained in this story may be outdated. COVID-19 vaccine side effects can vary depending on a person's age, sex, or health. Chills. Individuals with Type A blood type also represented a higher percentage of patients who succumbed to the illness 41 percent versus 25 percent for Type O. These include: chills fatigue fever. 8 Potential Bivalent Vaccine Side Effects. While this doesnt mean a free pass for anyone with a less susceptible blood type, it might help begin to solve some mysteries over why the coronavirus has more devastating effects on some individuals but not others. Diet is also key, and as you are probably well aware of by now if youve been following me a healthy microbiome is a must. She was also part of a clinical trial with danicopan, an oral complement factor D inhibitor. The Centers for Disease Control and Prevention (CDC) lists risk factors that have been identified for developing severe COVID-19, and blood type does not appear. Patient 4 is a 63-year-old man diagnosed with PNH 30 years ago, currently treated with ravulizumab. Redness and swelling at the . In populations at high-risk for exposure, such as healthcare workers, essential workers, and people exposed to a known case of the disease, the O blood type had an even greater protective effect, reducing the risk of acquiring the virus by 19 percent. There are some theories on why there could be a link: Your red blood cells are covered with molecules that are known as antigens, Thomas Russo, MD, professor and chief of infectious disease at the University at Buffalo, told Health. Although many vaccines can lead to hemolysis and thrombosis in PNH, this effect is mitigated in most patients on complement inhibitors.15 Ravulizumab, a new C5 inhibitor with a half-life 4 times longer than eculizumab, is reported to have significantly fewer instances of pharmacokinetic breakthrough hemolysis.16 Furthermore, 3 instances of breakthrough hemolysis occurred 4 weeks from the last ravulizumab infusion, making suboptimal C5 inhibition unlikely. Steam Room vs. Sauna: Which Is Better for You? It's important to note that individuals will react to these bivalent booster vaccines differently while the most common side effect is pain or swelling at the injection site, many people may feel more severe side effects, and unique combinations of the symptoms listed above. Researchers think the clotting may be triggered by the high . Your friend sits next to the person infected. S.C. has served on advisory boards for Alexion and Sanofi-Genzyme, and her institution has received research funding on her behalf from Takeda. Based on the currently available evidence, specific risk factors have not been confirmed, the EMA said. and elicited consistent side effects as compared to other COVID-19 vaccines, according to Dr. Martinello. Most side-effects are mild and short-lived, and some groups are more likely to get them than others. Furthermore, among ongoing clinical trials of immunotherapy using convalescent plasma or of SARS-CoV-2 vaccines, the interaction between participant blood groups and therapeutic efficacy could be measured.. Getty/David Greedy Common side effects include fatigue and headache Once a vaccine goes into your arm, your blood flow increases and immune cells rush to the scene. What scientists have learned is blood type seems to matter in at least two ways: Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. What does available data suggest about any side effects of a bivalent booster compared to a primary COVID-19 vaccine or earlier boosters administered in 2021? Side effects after getting a #COVID19 vaccine are normal signs your body is building protection. Got a question about COVID-19? He subsequently was initiated on ravulizumab, a terminal complement inhibitor. Common Moderna COVID-19 Vaccine side effects may include: fever, chills; redness or a hardness and swelling where the shot was given; swelling or tenderness under your arm; nausea, vomiting; feeling tired; or. Is this true? This is called a breakthrough infection. What should you have on hand at home? "Reassuring the public that everything is being done . Together, Drs. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. And would my blood type be part of my record at MIT Medical maybefrom lab work Ive had done in the past? His last dose of ravulizumab was 4 weeks prior to vaccination. We also present 2 patients with PNH who received the vaccine without significant adverse effects or hemolysis. 14% had at least one whole-body (systemic) after-effect - such as fever, aches or chills - within seven days of the first dose, rising to about 22% after the second dose These after-effects get. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. However, a genome-wide association study (GWAS) recently published in the New England Journal of Medicine (NEJM) is both consistent with, and potentially explains, these earlier results. Are the Vaccines Safe? The analysis turned up gene variants in two regions of the human genome that were associated with severe illness and greater risk of COVID-19-related death. Headache. Some previously young, healthy people who have developed COVID-19 have suffered strokes, possibly due . The other common side-effects the muscle aches, flu-like illness and fatigue are probably due to generalised activation of the immune system caused by the vaccine. Cambridge, MA 02142, MIT Lincoln Laboratory 244 Wood Street COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. Information and statements regarding dietary supplements/products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Conflict-of-interest disclosure: R.A.B. "It'll be intriguing to see what we learn from this new study.". Some people experience a little discomfort and can continue to go about their day. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting. As a result, our understanding of the connection to blood type continues to evolve. These include soreness where the jab was. These studies only suggest an association between blood types and Covid-19 outcome, not cause and effect. Do COVID-19 vaccines and boosters raise your blood sugar? Blood type has been identified as a risk factor in many diseases, from cancer to venous and arterial thromboembolism. Studies of the accuracy of serologic tests for anti-SARS-CoV-2 immunoglobulins may assess whether there is variation in antibody titers by ABO and Rh status, the authors noted. According to materials published by the American Medical Association, research on the timing between infection and another injection indicates that an increased timeline in this range could better bolster your body's immune response compared to receiving a shot earlier. You may know that blood type A individuals can't donate blood to people with type B blood. The authors of the NEJM study hypothesize that different combinations of A and B antigens may change how the immune system produces infection-fighting antibodies or have some other, unknown effect on how the body responds to infection. Fatigue, headaches, muscle and joint aches and fever are all potential side effects as well. The MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab. Secondary outcome results indicated that type O blood group had an aRR of 0.87 (95% CI, 0.78-0.97) for severe COVID-19 illness and death versus all other blood groups and Rh- status had an aRR of 0.82 (95% CI, 0.680.96) compared to Rh+ status. There have been multiple studies on blood types and COVID-19 risk. People react differently after being vaccinated. The blood group types did not affect the clinical outcomes. muscle pain . loss of smell. "As an individual, you have your blood typethere's nothing you can do about it.". These cases have been mild and self-resolving. Researchers looked at health data from more than 14,000 patients with COVID-19 and found a slightly increased infection prevalence among non-O types. Computed tomography with contrast showed peripancreatic fat stranding with normal lipase, concerning for possible small bowel microvascular thrombosis. There is a higher risk of myocarditis from COVID itself than there is from . But weve known for a while that the coronavirus responsible for COVID-19 gets into cells by attaching to angiotensin-converting enzyme (ACE) 2 receptors and that the disease can affect blood clotting, causing cardiovascular and cardiopulmonary problems. We recommend vaccination within 4 weeks of the last ravulizumab infusion and 1 week of eculizumab infusion and that patients maintain optimal hydration. "The other half is focused on the new sub-variants that have been causing nearly all the disease we've been seeing over the past few months.". This "Covid arm" rash can be red, itchy, swollen, or painful. Virologists and vaccine experts explore what we know below. Possible side effects: The side effects are similar to Pfizer-BioNTech's vaccine: Pain, redness, or swelling at the site where the shot was administeredand/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Blood 2021; 137 (26): 36703673. associate medical director of infection prevention at UCI Health and a professor at the University of California, Irvine, posits an analogy that this bivalent vaccine is like a riff on a standard brownie recipe: "You're going to have almost the same ingredients, and bake it for the same time at the same temperature but this time, instead of just chocolate chips, you add dark chocolate, too," she tells Good Housekeeping. That is not to say that there have never been safety issues with vaccines. Chills,. A Vancouver study revealed people with blood types A, B or AB had worse outcomes than others. These usually last from a few hours to a few days after vaccination. And, in fact, these researchers, like the researchers in China and New York City, found a higher risk for severe illness among individuals with Type A blood and a protective effect for Type O. Patient 1 is a 25-year-old man diagnosed with PNH 6 months prior in the setting of hemoglobinuria and had limited disease manifestations not requiring PNH-directed therapy. For all four vaccines, pain at the injection site. Blood clotting is a well-recognized complication of SARS-CoV-2 infection. It also can be potentially quite large and thus a bit unsettling. Patient 1 had a presumptive thrombotic manifestation. However, cases remain very rare: the MHRA noted 79 cases of blood clots with low platelets, including 19 deaths, following more than 20m doses of the AstraZeneca jab, with 44 of the cases and 14 of the deaths related to a rare type of blood clot in the brain called cerebral venous sinus thrombosis (CVST) that occurred with a low platelet count. If you have or suspect that you have a medical problem, contact your healthcare provider promptly. Similarly, type B individuals only have anti-A antibodies. The AstraZeneca and J&J jabs are based on a similar technology. On the evening after his first dose of the Pfizer-BioNTech vaccine, he experienced fever, headache, myalgia, and severe fatigue, which lasted 6 days. Health's content is for informational and educational purposes only. This is why learning from Body Ecology, from doctors, and from other practitioners in our space is important. "At the end of the day, we're still not sure if blood type makes a difference," said Dr. Russo. However, as the situation surrounding COVID-19 continues to evolve, it's possible that some data have changed since publication. Instead, being armed with greater knowledge about your blood type could provide extra incentive to be cautious and build your immune system. All in all, more than 1 million people were involved. 1 vaccines. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. Ray JG, Schull MJ, Vermuelen MJ, Park A. Symptoms of long COVID. Both use cold viruses that cannot replicate to deliver instructions for making the coronavirus spike protein into human cells: the cells then produce the protein, triggering an immune response. This single nucleotide polymorphism (SNP) is a T at the rs505922 location on the gene. Although many vaccines can lead to hemolysis and thrombosis in PNH, this effect is mitigated in most patients on complement inhibitors. It is not clear to me why. Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19, while those with blood type O are less likely to test positive for the virus. Association between ABO and Rh blood groups and SARS-CoV-2 infection or severe COVID-19 illness. The US Food and Drug Administration has recommended pausing use of the jab while J&J has announced it would proactively delay the rollout of our vaccine in Europe. Thank you for submitting a comment on this article. "The side effects that we see occur early on and that's it," Goepfert said. Health Canada and PHAC are aware of an updated report released on Monday February 6, 2023 by the Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA) on findings from the Vaccine Safety Datalink. Since those studies, a fair amount of research has been conducted on blood type and COVID-19 risk. Blood types can also serve as receptors for viruses and bacteria, and that could be another factor, explained Dr. Russo, there may be some other, completely different component of type O blood that works to prevent infection. Should you eat before? This difference in risk of testing positive for COVID-19 seemed to hold even when researchers took into account age, sex, body mass index, ethnicity, and co-morbidities (i.e., pre-existing conditions like heart disease and diabetes). For the AstraZeneca jab, it seems such side-effects are more common after the first shot. The answer remains elusive but may be connected to how the virus attaches itself to your cells and how your genes influence the number and type of receptors on those cells, as well as to your overall risk of cardiovascular problems. Although the chance of any person receiving the vaccine experiencing a blood clot with low platelets is extremely small, because the risk of severe Covid in the under-30s with no underlying illness is also small, JCVI feel as a precautionary measure it is appropriate for those in this age group to be offered an alternative Covid vaccine when their turn comes for their first dose of a vaccine, said Prof Anthony Harnden, deputy chair of the JCVI. Recent research is suggesting that your blood type may affect your risk of getting COVID-19 and could influence the severity of the disease. In patients with severe disease, deposition of terminal complement and microthrombosis have been observed in the lung, skin, kidney, and heart.14 Recently, we demonstrated that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein leads to amplification of the alternative pathway of complement on cell surfaces through competition with complement factor H (CFH) for binding heparan sulfate.5 Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells. Using this data, 23andMe launched their COVID-19 Severity Calculator last year. In addition to the lungs, blood clots, including those associated with COVID-19, can also harm: The nervous system. Following his second dose, he noted fevers, diarrhea, vomiting, severe fatigue, and dark urine. Other countries have taken different approaches: in France the AstraZeneca jab is now only to be given to those aged 55 and over, while in Germany it is offered to those aged 60 and over. 25 Carleton Street "All may acquire COVID-19 and all should take the recommended precautions to reduce the risk.". Since the formulation of this particular round of bivalent booster vaccines was made in a very similar process to earlier options, experts aren't expecting any new subsets of potential side effects to present this fall. A transcript of the podcast is below the summary. The spread of new variants can also increase the risk of reinfection. This unusual clotting may cause different complications, including organ damage, heart attack and stroke.

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